Pre-exposure Prophylaxis (PrEP) for SARS-Coronavirus-2:

A Pragmatic Randomized Clinical Trial

Thank you very much for your interest in our study!

Currently we are no longer enrolling participants for this study. Future updates regarding results of this study will be posted on our website in the coming months once the follow-up period has been completed.

Thanks again,

The Canadian COVID-PrEP team

COVID-19 disease is caused by a virus called severe acute respiratory syndrome coronavirus 2, or SARS-CoV-2 for short. In conjunction with the University of Minnesota in the United States, the University of Manitoba and Research Institute of the McGill University Health Centre are conducting a research study to determine if taking a medication called hydroxychloroquine can help in preventing COVID-19 disease.

The concept is called “pre-exposure prophylaxis” — a method where medication is given to prevent an infectious disease before contacting an infected person. This strategy has proven useful for infections like HIV.

Hydroxychloroquine is a drug already approved for the treatment of malaria and has been used for the prevention of malaria for over 50 years. It is also sometimes used to treat autoimmune diseases such as rheumatoid arthritis or lupus. There is some evidence that hydroxychloroquine may have activity against the SARS-CoV-2 virus, but at this time we do not know if it may work as a pre-exposure prophylaxis therapy.

We are seeking research participants who are healthcare workers, at high risk of COVID-19 exposure:

Persons primarily working in emergency departments (ex. physicians, nurses, ancillary staff, triage personnel)

Persons primarily working in intensive care units (ex. physicians, nurses, ancillary staff, respiratory therapists)

Persons performing aerosol generating procedures (ex. anesthesiologists, nurse anesthetists)

Persons working in a long-term care facility with a previous or current outbreak of COVID-19

First responders (ex. EMTs, paramedics)

Click here for more information on hydroxychloroquine:

To see if you are eligible, review the study details

A clinical trial is not a substitute for medical advice. The Government of Canada Screening tool and information about COVID-19 can be found here: If you are having symptoms, reduce your contact with others, call your health care provider and follow the instructions provided by your Provincial Health Authority. If you are having severe symptoms, call 911. Provincial COVID-19 screening tools are available here:

In Manitoba

In Quebec